A one dose syringe, comprising a freeze-dried protein...

A - Human Necessities – 61 – M

Patent

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Details

A61M 5/19 (2006.01) A61K 9/19 (2006.01) A61K 38/27 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2311754

The invention relates to a one-dose syringe comprising a first chamber with a freeze-dried composition comprising a protein in an amount of less than 1.4 mg, amino acid and stabilizer where the weight ratio between protein and amino acid versus stabilizer is less than 1.5 and in which the ratio of the weight of the dry component versus the cake volume in the first chamber is above 12 mg/ml and a second chamber with an aqueous reconstitution solution with an injectable volume of less than 0.5 ml.

L'invention concerne une seringue monodose comportant une première chambre renfermant une composition lyophilisée comprenant une protéine dont la dose est inférieure à 1,4 mg, un acide aminé et un stabilisant. Le rapport pondéral entre la protéine et l'acide aminé par rapport au stabilisant est inférieur à 1,5. Le rapport entre le poids du composant sec et le volume de l'agglomérat dans la première chambre est supérieur à 12 mg/ml. Cette seringue comporte également une seconde chambre renfermant un volume injectable inférieur à 0,5 ml d'une solution de reconstitution aqueuse.

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