C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2404310
The invention provides isolated nucleic acid molecules, designated SLIC-1 nucleic acid molecules, which encode novel P-selectin glycoprotein ligand (PSGL-1) binding molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SLIC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman trangenic animals in which a SLIC-1 gene has been introduced or disrupted. The invention still further provides isolated SLIC-1 proteins, fusion proteins, antigenic peptides and anti-SLIC-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
L'invention concerne des molécules isolées d'acides nucléiques, dénommées molécules SLIC-1, qui codent pour de nouvelles molécules de liaison aux ligands de glycoprotéine P-sélectine (PSLG-1). L'invention concerne également des molécules d'acides nucléiques antisens, des vecteurs d'expression recombinants contenant les molécules SLIC-1, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits, et des animaux transgéniques non humains dans lesquels un gène SLIC-1 a été introduit ou dissocié. L'invention concerne en outre des protéines SLIC-1 isolées, des protéines de fusion, des peptides antigéniques et des anticorps anti-SLIC-1. L'invention concerne enfin des méthodes diagnostiques qui utilisent des compositions de la présente invention.
Kriz Ron
Lorenz Meike
Shaw Gray D.
Weich Nadine
Genetics Institute Llc
Torys Llp
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