A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 39/04 (2006.01) A61K 39/40 (2006.01) C07K 14/35 (2006.01) C12N 1/12 (2006.01) G01N 33/53 (2006.01) G01N 33/531 (2006.01) G01N 33/533 (2006.01) G01N 33/542 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2464713
The present invention provides an assay for detection of M. bovis-infected animals. A tracer, comprising a peptide of M. bovis protein MPB70 conjugated to a fluorophore, is added to a serum sample from an animal to form a mixture. The fluorescence polarization of the mixture in then measured and compared to the fluorescence polarization of a control. The present invention further provides a tracer for use in fluorescence polarization assay to detect antibodies specific for M. bovis. The tracer comprises a peptide of M. bovis protein MPB70 conjugated to a fluorophore, such that the tracer is able to bind to antibodies specific for M. bovis to produce a detectable change in fluorescence polarization.
L'invention se rapporte à une analyse permettant la détection d'animaux infectés par M. bovis. Un traceur, comprenant un peptide d'une protéine MPB70 de M. bovis conjugué à un fluorophore, est ajouté à un échantillon de sérum d'un animal pour former un mélange. La polarisation de fluorescence du mélange est alors mesurée et comparée à la polarisation de fluorescence d'un témoin. L'invention concerne en outre un traceur s'utilisant dans une analyse de polarisation de fluorescence pour détecter des anticorps spécifiques pour M. bovis. Ledit traceur comprend un peptide de la protéine MPB70 de M. bovis conjugué à un fluorophore, de sorte que le traceur peut se lier à des anticorps spécifiques pour M. bovis, afin de produire un changement observable dans la polarisation de fluorescence.
Jolley Michael E.
Nasir Mohammad Sarwar
Romanowska Anna
Surujballi Om P.
Diachemix Llc
Her Majesty The Queen In Right Of Canada As Represented By The C
Mbm Intellectual Property Law Llp
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