A pharmaceutical composition

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 333/20 (2006.01) A61K 9/00 (2006.01) A61K 31/381 (2006.01) A61P 25/16 (2006.01)

Patent

CA 2761427

The present invention relates to new salts of 6-(propyl-(2-thiophen-2- ylethyl)amino)tetralin-1- ol (rotigotine), their use as a medicament, for example for the treatment of CNS disorders like Parkinson Disease, RLS, fybromyalgia and/or depres-sion, in particular through electromotive administration. The present invention relates to pharmaceutical formulations suitable for iontophoresis that provide enhanced iontophoretic delivery of rotigotine to at least one target tissue. The formulations are further characterized by good to excellent solubility of the salts in aqueous solutions.

La présente invention concerne de nouveaux sels de 6-(propyl-(2-thiophén-2-yléthyl)amino)tétralin-1-ol, c'est-à-dire de rotigotine, leur utilisation comme médicament destiné notamment au traitement de troubles affectant le système nerveux central, comme la maladie de Parkinson, le syndrome des jambes sans repos ou "RLS" (Restless Leg Syndrom), la fibromyalgie et/ou la dépression, en particulier par administration par voie électromotrice. L'invention concerne également des formulations pharmaceutiques convenant à l'ionophorèse et assurant une meilleure administration par ionophorèse de la rotigotine, en direction d'au moins un tissu cible. Ces formulations sont caractérisées en outre par une solubilité bonne à excellente des sels dans des solutions aqueuses.

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