A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/13 (2006.01) A61K 9/107 (2006.01) A61K 9/127 (2006.01) A61K 47/14 (2006.01)
Patent
CA 2352388
A pharmaceutical composition comprising a cyclosporin as an active substance in a lipid carrier, which carrier comprises membrane lipids in combination with monoglycerides and optionally non-polar lipids, which composition is characterized in being liquid at room temperature and containing 0.5-25 % cyclosporin, 10-45 % membrane lipids, 10-55 % monoglycerides and 0-45 % non- polar lipids. A composition of the invention is bioequivalent to a commercial drug containing in addition to cyclosporin and additives also toxic emulsifiers and ethanol.
Composition pharmaceutique contenant une cyclosporine en tant que substance active dans un véhicule lipidique comprenant des lipides membranaires combinés à des monoglycérides et éventuellement à des lipides non polaires, cette composition étant caractérisée par le fait qu'elle est liquide à température ambiante et contient 0,5-25 % de cyclosporine, 10-45 % de lipides membranaires, 10-55 % de monoglycérides et 0.45 % de lipides non polaires. Cette composition présente une bioéquivalence par rapport à un médicament commercialisé contenant en plus de la cyclosporine et d'additifs, également des émulsifiants toxiques et de l'éthanol.
Herslof Bengt
Kaufmann Peter
Kroon Carl-Gunnar
Lipocore Holding Ab
Mccarthy Tetrault Llp
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