A pharmaceutical composition for angiotensin ii-mediated...

Details A pharmaceutical composition for angiotensin ii-mediated... A pharmaceutical composition for angiotensin ii-mediated...

A - Human Necessities

61

K

A61K 31/415 (2006.01) A61K 31/495 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2125251

This invention relates to a pharmaceutical composition of angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula (See formula I) wherein R1 is H or an optionally substituted hydrocarbon residue; R2 is an optionally esterified carboxyl group; R3 is a group capable of forming an anion or a group convertible thereinto; X is a covalent bond between the 2 phenyl rings or a spacer having a chain length of 1 to 2 atoms as the linear moiety between the adjoining phenylene group and phenyl group; n is 1 or 2; the ring A is a benzene ring having 1 or 2 optional substituents in addition to R2; and Y is a bond, -O-, -S(O)m-(wherein m is 0, 1 or 2) or -N(R4)- (wherein R4 is H or an optionally substituted alkyl group), or a pharmaceutically acceptable salt thereof in combination with a compound having diuretic activity or a compound having calcium antagonistic activity.

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