A pharmaceutical composition for the prevention and...

A - Human Necessities – 61 – K

Patent

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A61K 45/06 (2006.01)

Patent

CA 2525225

Pharmaceutical compositions are disclosed for the treatment of nicotine dependence or addiction, tobacco dependence or addiction, reduction of nicotine withdrawal symptoms or aiding in the cessation or lessening of tobacco use or substance abuse or other behavioral dependencies. The pharmaceutical compositions are comprised of a therapeutically effective combination of a nicotinic receptor partial agonist and a CB-1 receptor antagonist and a pharmaceutically acceptable carrier. The method of using these compounds is also disclosed.

La présente invention porte sur des compositions pharmaceutiques destinées au traitement de la dépendance ou de l'accoutumance à la nicotine et au tabac, à atténuer les effets des thérapies de sevrage à la nicotine ou utilisées comme aide à la désaccoutumance ou à la diminution de la consommation de tabac, d'abus de substances ou de dépendances comportementales. Les compositions pharmaceutiques comprennent une combinaison efficace sur le plan thérapeutique d'un agoniste partiel des récepteurs nicotiniques et d'un antagoniste du récepteur CB-1 ainsi qu'un véhicule acceptable sur le plan pharmaceutique. L'invention porte également sur le mode d'emploi de ces composés.

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