A pharmaceutical composition for the treatment of depression...

A - Human Necessities – 61 – K

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A61K 45/00 (2006.01) A61K 31/341 (2006.01) A61K 31/41 (2006.01) A61K 31/4245 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/4402 (2006.01) A61K 31/4406 (2006.01) A61K 31/4439 (2006.01) A61P 25/24 (2006.01) A61P 43/00 (2006.01) C07D 213/71 (2006.01) C07D 277/36 (2006.01) C07D 307/64 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2440374

Remedies and/or preventives for depression containing as the active ingredient a compound (an EP1 antagonist) having antagonism to EP1 receptor which is one of prostaglandin E2 receptor subtypes. The EP1 antagonist is useful in treating depression (for example, endogenous depression, reactive depression, weatherproof depression, neurogenic depression, depression associating organic mental disorder).

L'invention concerne des remèdes et/ou des préventifs antidépresseurs contenant, en tant qu'ingrédient actif, un composé (un antagoniste EP¿1?) possédant un antagonisme vis à vis du récepteur EP¿1 ?qui est l'un des sous-types de récepteur de prostaglandine E¿2. ?L'antagoniste EP¿1? est utile dans le traitement des dépressions (par exemple, la dépression endogène, la dépression réactionnelle, la dépression saisonnière, la dépression neurogène, la dépression associée à un trouble mental organique).

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