A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 38/20 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/715 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2280998
The invention provides a pharmaceutical composition for the treatment of hepatitis B virus (HBV) infection, comprising an amount of a soluble active agent which interacts with at least one of the binding sites between hIL6 and pS1 and between hIL6 and hepatocytes and other HBV-permissive cells, the active agent being present in sufficient amount to competitively bind to at least one of the sites and thereby to prevent hIL6-mediated HBV infection of hepatocytes and other HBV-permissive cells.
L'invention concerne une composition pharmaceutique destinée au traitement de l'infection par le virus de l'hépatite B (HBV), renfermant une dose d'un agent actif soluble qui interagit avec au moins un des sites de fixation entre hIL6 et pS1 et entre hIL6 et des hépatocytes, ainsi que d'autres cellules permissives du HBV, l'agent actif étant présent en une dose suffisante pour se fixer, de façon compétitive, à au moins un des sites et, par conséquent, pour prévenir l'infection à HBV induite par hIL6 d'hépatocytes et d'autres cellules permissives du HBV.
Blum Hubert E.
Galun Eithan
Nahor Orit
Hadasit Medical Research Services & Development Company Ltd.
Riches Mckenzie & Herbert Llp
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