A pharmaceutical composition for treating immune diseases

A - Human Necessities – 61 – K

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A61K 45/00 (2006.01) A61K 31/7105 (2006.01) A61K 31/711 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2348954

An antibody against AILIM (alternatively called JTT-1 antigen, JTT-2 antigen, ICOS and 8F4) was found to have a significant therapeutic effect on arthrosis, for example, rheumatoid arthritis and osteoarthritis, graft versus host disease, graft immune rejection, inflammation (hepatitis and inflammatory bowel diseases), diseased condition accompanied by the excessive production of an antibody against a foreign antigen triggered by immunological sensitization by the antigen.

L'invention concerne la découverte selon laquelle les anticorps dirigés contre AILIM (également appelé antigène JTT-1, antigène JTT-2, ICOS et 8F4) produisent des effets thérapeutiques importants sur des maladies articulaires telles que le rhumatisme articulaire, la polyarthrite rhumatoïde, la réaction du greffon contre l'hôte, le rejet immunitaire de transplantation, l'inflammation (hépatite, maladies inflammatoires, etc.), sur les symptômes associés à une sensibilisation immunitaire par un antigène étranger, et l'hyperproduction d'un anticorps ainsi induite contre cet antigène.

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