A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01)
Patent
CA 2661665
Disclosed herein are a pharmaceutical composition for inhibiting the proliferation or metastasis of lung cancer cells, comprising a substance inhibiting the activity of LlCAM or suppressing the expression of LlCAM, which is a protein present on the surface of lung cancer cells, and a treatment method using the composition. Mouse monoclonal antibodies, recognizing the LlCAM protein on the SCLC cell surface and binding specifically to SCLC tissues, or siRNAs, ant i sense oligonucleotides or shRNAs, may be useful in the treatment of lung cancer by inhibiting the growth, invasion and migration of lung cancer cell.
L'invention concerne une composition pharmaceutique destinée à inhiber la prolifération ou le développement de cellules métastatiques du cancer du poumon, comprenant une substance qui inhibe l'activité de la LICAM ou qui en empêche l'expression, la LICAM étant une protéine présente à la surface des cellules cancéreuses du poumon, ainsi qu'une méthode de traitement faisant intervenir cette composition. Des anticorps monoclonaux de souris, reconnaissant la protéine LICAM à la surface cellulaire des SCLC et se liant spécifiquement aux tissus des SCLC, des ARNsi, des oligonucléotides anti-sens ou des ARNsh, peuvent être utiles dans le traitement du cancer du poumon du fait qu'ils inhibent la croissance, la dissémination et la migration des cellules cancéreuses du poumon.
Hong Hyo Jeong
Kim Jin Man
Lee Eung Suck
Lee Jung-Whoi
Son Yeon Sung
Korea Research Institute Of Bioscience And Biotechnology
Ridout & Maybee Llp
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