A pharmaceutical formulation and its use in the treatment of...

A - Human Necessities – 61 – K

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A61K 9/08 (2006.01) A61K 9/00 (2006.01) A61K 31/495 (2006.01)

Patent

CA 2493289

A new pharmaceutical formulation, especially for trans-tympanic or intra- trans~tympanic administration, containing a quinoxalin-2-one compound of the formula (I) in which R1 and R2, independently of one another, are hydrogen, methyl-, ethyl-, propyl-, butyl- or R1 and R2 together are a cyclo-alkyl compound; R3 is methoxy, ethoxy, hydroxy, hydrogen, C1-C4 alkyl or halogen, and n = 1, 2 or 3, or a pharmaceutically compatible salt of the afore- mentioned derivatives, and in addition an effective amount of a permeability accelerator of the afore-mentioned quinoxalin-2-one compound, as well as, if necessary, a pharmaceutically compatible a solvent.

Cette invention se rapporte à une nouvelle formulation pharmaceutique, conçue notamment pour une administration trans-tympanique ou intra-trans-tympanique, contenant un composé de quinoxalin-2-one représenté par la formule (I), où R1 et R2, représentent séparément l'un de l'autre, hydrogène, méthyl-, éthyl-, propyl-, butyl- ou R1 et R2 représentent ensemble un composé cyclo-alkyle ; R3 représente méthoxy, éthoxy, hydroxy, hydrogène, alkyle C1-C4 ou halogène, et n est égal à 1, à 2 ou à 3, ou un sel pharmaceutiquement compatible des dérivés mentionnés ci-dessus, et en outre une quantité efficace d'un accélérateur de perméabilité du composant de quinoxalin-2-one mentionné ci-dessus, ainsi que, si nécessaire, un solvant pharmaceutiquement compatible.

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