A pharmaceutical formulation comprising a low molecular...

A - Human Necessities – 61 – K

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Details

A61K 38/55 (2006.01) A61K 38/04 (2006.01) A61K 38/06 (2006.01) A61P 9/14 (2006.01)

Patent

CA 2371008

According to the invention there is provided a kit of parts comprising: (a) a pharmaceutical formulation including a low molecular weight thrombin inhibitor, or a pharmaceutically acceptable derivative thereof, in admixture with a pharmaceutically acceptable adjuvant, diluent or carrier; and (b) a pharmaceutical formulation including a produg of a low molecular weight thrombin inhibitor, or a pharmaceutically acceptable derivative of that prodrug, in admixture with a pharmaceutically acceptable adjuvant, diluent or carrier, which components (a) and (b) ar each provided in a form that is suitable for administration in conjunction with the other, as well as the use of such a kit of parts in the treatment of a condition in which inhibition of thrombin is required or desired.

L'invention se rapporte à une trousse contenant (a) une solution pharmaceutique comportant un inhibiteur de thrombine de faible poids moléculaire, ou un dérivé pharmaceutiquement acceptable d'un tel inhibiteur, mélangé à un adjuvant pharmaceutiquement acceptable, et (b) une formulation pharmaceutique comportant un promédicament dudit inhibiteur de thrombine de faible poids moléculaire, ou un dérivé pharmaceutiquement acceptable d'un tel promédicament, mélangé avec un adjuvant, diluant ou excipient pharmaceutiquement acceptable. Lesdits composés (a) et (b) se présentent tous deux sous une forme qui permet de les administrer conjointement à l'autre. L'invention se rapporte également à un procédé d'utilisation de cette trousse pour le traitement d'un trouble pour lequel il est nécessaire ou souhaité d'inhiber la thrombine.

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