A physically and chemically stable nicotine-containing...

A - Human Necessities – 61 – K

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Details

A61K 31/465 (2006.01) A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/68 (2006.01)

Patent

CA 2511185

A nicotine-containing particulate material for release of nicotine, the material comprising a combination of nicotine or a pharmaceutically acceptable salt, complex or solvate thereof and a microcrystalline cellulose, The particulate material is stable upon storage and releases nicotine relatively fast. The particulate material can be used in the manufacture of nicotine- containing pharmaceutical composition, wherein the release of nicotine can be designed to be relatively fast so as to obtain a fast onset of action.

La présente invention concerne un matériau particulaire contenant de la nicotine destiné à libérer de la nicotine. Ce matériau comprend une combinaison de nicotine ou d'un sel, d'un complexe ou d'un solvate de ce composé répondant aux normes pharmaceutiques et d'une cellulose microcristalline. Ce matériau est stable lors du stockage et libère de la nicotine relativement rapidement. On peut utiliser ce matériau particulaire dans la fabrication de composition pharmaceutique contenant de la nicotine, la libération de la nicotine étant programmée pour être relativement rapide de façon à obtenir une action survenant rapidement.

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