A pkn3/rhoc macromolecular complex and methods of use therefor

Details A pkn3/rhoc macromolecular complex and methods of use therefor A pkn3/rhoc macromolecular complex and methods of use therefor

G - Physics

01

N

G01N 33/50 (2006.01) A61K 39/00 (2006.01) C07K 14/00 (2006.01)

Patent

CA 2753883

Disclosed are compositions comprising and methods of using a novel macromolecular assembly comprising PKN3, PDK1 and RhoC (PPRC complex). The PPRC complex was shown to have kinase activity and was found in cells of high malig-nancy potential, such as particularly aggressive cancers. In some aspects, the invention provides methods for screening com-pounds that have cancer therapeutic potential, methods for diagnosing aggressive cancer, methods for determining the prognosis of a patient suffering from cancer, methods for stratifying patients in a clinical trial or determining the effectiveness of a particular treatment regimen, polypeptides that modulate the formation of the PPRC complex, and kits comprising one or more components of the PPRC complex.

L'invention porte sur des compositions comprenant un nouvel ensemble macromoléculaire comprenant PKN3, PDK1 et RhoC (complexe PPRC), et sur des procédés d'utilisation de ce nouvel ensemble. Il a été démontré que le complexe PPRC a une activité kinase et a été trouvé dans des cellules de potentiel élevé de malignité, telles que des cancers particulièrement agressifs. Sous certains aspects, l'invention porte sur des procédés de criblage de composés qui ont un potentiel thérapeutique contre le cancer, sur des procédés de diagnostic d'un cancer agressif, sur des procédés de détermination du pronostic d'un patient souffrant d'un cancer, sur des procédés d'évaluation du stade de patients dans un essai clinique ou de détermination de l'efficacité d'un régime de traitement particulier, sur des polypeptides qui modulent la formation du complexe PPRC et sur des trousses comprenant un ou plusieurs composants du complexe PPRC.

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