C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A61K 39/00 (2006.01) A61K 39/12 (2006.01) A61K 39/21 (2006.01) A61K 39/245 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2219339
The present invention is directed to compositions and methods for the induction of immune responses in mammals against enveloped animal viruses. More particularly, the invention provides vaccine compositions containing multiple MHC allotypes. By generating an immune response against these MHC molecules, virus or virus-infected cells expressing foreign MHC molecules can be attacked prior to infection of cells in the immunized host. In some embodiments, the vaccine compositions contain viral antigens and adjuvants as well. The vaccine compositions may comprise intact cells, cell-derived membrane preparations or recombinantly or chemically produced MHC molecules or fragments thereof.
La présente invention concerne des compositions et des procédés pour l'induction de réponses immunitaires chez des mammifères contre des virus animaux à enveloppe. Plus particulièrement, l'invention décrit des compositions de vaccin contenant de multiples allotypes CMH. La production d'une réponse immunitaire contre ces molécules CMH permet d'attaquer, avant l'infection des cellules chez l'hôte immunisé, un virus ou des cellules infectées par virus exprimant des molécules CMH étrangères. Dans certains modes de réalisation, les compositions de vaccin contiennent des antigènes viraux ainsi que des adjuvants. Ces compositions peuvent comporter des cellules intactes, des préparations membranaires dérivées de cellules ou bien des molécules CMH produites par recombinaison ou par voie chimique ou encore des fragments de celles-ci.
Bereskin & Parr
John Wayne Cancer Institute
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