A polymeric wrap for in vivo delivery of osteoinductive...

A - Human Necessities – 61 – F

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A61F 2/30 (2006.01) A61L 27/34 (2006.01) A61L 27/54 (2006.01)

Patent

CA 2579025

The application discloses a polymeric wrap having one or more osteoinductive formulations, wherein each osteoinductive formulation comprises one or more osteoinductive agent(s). In one embodiment, the osteoinductive formulation(s) is contained within a biodegradable polymer sheet. In another embodiment of the invention, the polymeric wrap comprises at least two or more individual biodegradable polymer sheets or layers optionally comprising osteoinductive formulation(s) comprising at least one osteoinductive agent. The osteoinductive formulations are available in immediate or sustained release formulations. The method further relates to preventing and treating osteolytic lesions formed following implantation of an orthopaedic device or other implant.

L'invention concerne un emballage polymère pour la délivrance in vivo d'une ou plusieurs formulations ostéoinductrices, chaque formulation comprenant un ou plusieurs agents ostéoinducteurs. Selon une variante, la ou les formulations se trouvent dans une feuille polymère biodégradable. Selon une autre variante, l'emballage comprend au moins deux ou plus de deux feuilles ou couches de ce type qui renferment la ou les formulations contenant au moins un agent ostéoinducteur. Les formulations sont disponibles sous forme à libération immédiate ou prolongée. Le procédé décrit concerne la prévention et le traitement des lésions ostéolytiques résultant de l'implantation d'un dispositif orthopédique ou autre implant.

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