A polypeptide and dna thereof useful as a neovascular marker

Details A polypeptide and dna thereof useful as a neovascular marker A polypeptide and dna thereof useful as a neovascular marker

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/02 (2006.01) A61K 39/395 (2006.01) A61P 9/00 (2006.01) A61P 15/00 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2446327

A marker for neovascularization, vascular disease, inflammatory disease, entoptic neovascular disease, reproductive system disease, central nervous system disease and cancer, the method of detection of the marker and a diagnosis kit of the diseases are provided. Additionally, therapeutic agents of the diseases are provided. The expression of KIAA1036 is enhanced in ovarian cancer and large bowel cancer and KIAA1036 expresses in umbilical vein endothelial cell and inhibits DNA synthesis in the cells, cell migrating and lumen formation. Therefore KIAA1036 is useful as a marker for neovascularization, vascular disease, inflammatory disease, entoptic neovascular disease, reproductive system disease, central nervous system disease or cancer. Additionally, KIAA1036 is useful for screening of agonists, antagonists, DNA synthesis inhibitors, cell migrating inhibitors and neovascular inhibitors. The substances obtained by the screening, KIAA1036 and the antibodies are useful as therapeutic agents the above disease.

L'invention concerne un marqueur pour angiogenèse, maladies vasculaires, maladies inflammatoires, maladies angiogéniques intraoculaires, maladies génitales, maladies du système nerveux central et cancers. Elle concerne un procédé permettant de les détecter, ainsi qu'une trousse conçue pour diagnostiquer ces maladies et des médicaments pour les traiter. KIAA1036 montre l'expression dans le cancer de l'ovaire et le cancer du côlon, ainsi que l'expression dans des cellules épithéliales de veines ombilicales et a pour effet d'inhiber la synthèse d'ADN dans ces cellules, la migration cellulaire et la formation de lumières. Compte tenu de ces caractéristiques, KIAA1036 peut être utilisé comme marqueur pour angiogenèse, maladies vasculaires, maladies inflammatoires, maladies angiogéniques intraoculaires, maladies génitales, maladies du système nerveux central et cancers. KIAA1036 peut également être utilisé au niveau du criblage d'un agoniste, d'un antagoniste, d'un inhibiteur de synthèse d'ADN, de migration cellulaire, d'angiogenèse, etc. Des substances obtenues par criblage, ainsi que KIAA1036 et son anticorps sont des remèdes utiles contre de telles maladies.

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