A polypeptide comprising the amino acid of an n-terminal...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/10 (2006.01) A61K 39/09 (2006.01) A61K 39/395 (2006.01) A61P 31/04 (2006.01) C07K 14/315 (2006.01) C07K 16/12 (2006.01) C12N 5/10 (2006.01) C12N 15/31 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2326388

This invention provides an isolated polypeptide comprising an amino acid sequence of an N-terminal choline binding protein A truncate in which the amino acid sequence is set forth in any of SEQ ID NOS: 1,3-7, or 9-11, including fragments, mutants, variants, analogs, or derivatives, thereof. Also, this invention provides isolated polypeptides comprising an amino acid sequence of a N-terminal choline binding protein A truncate, wherein the amino acid is set forth in SEQ ID NO 24, wherein the polypeptide retains its native tertiary structure and methods of preparation. This invention provides an isolated polypeptide comprising an amino acid sequence of an N-terminal choline binding protein A truncate, wherein the polypeptide has lectin activity and does not bind to choline. This invention provides an isolated immunogenic polypeptide comprising an amino acid sequence of an N-terminal choline binding protein A truncate. This invention provides an isolated nucleic acid encoding a polypeptide comprising an amino acid sequence of N- terminal choline binding protein A truncate. Lastly, this invention provides pharmaceutical compositions, vaccines, and diagnostic and therapeutic methods of use.

L'invention concerne un polypeptide isolé comprenant une séquence d'acides aminés d'un produit tronqué de la protéine A N-terminale fixant la choline, laquelle séquence apparaît dans SEQ ID NOS: 1, 3-7 ou 9-11, y compris les fragments, mutants, variants, analogues ou dérivés de ce polypeptide. L'invention concerne également un polypeptide isolé comprenant une séquence d'acides aminés d'un produit tronqué de la protéine A N-terminale fixant la choline, où l'acide aminé apparaît dans SEQ ID NO 2, où le polypeptide conserve sa structure tertiaire d'origine. L'invention concerne également les méthodes d'élaboration de ce polypeptide. L'invention concerne également un polypeptide isolé comprenant une séquence d'acides aminés d'un produit tronqué de la protéine A N-terminale fixant la choline, où le polypeptide présente une activité de lectine et ne fixe pas la choline. L'invention concerne également un polypeptide isolé immunogène comprenant une séquence d'acides aminés d'un produit tronqué de la protéine A N-terminale fixant la choline. L'invention concerne également un acide nucléique isolé codant un polypeptide comprenant une séquence d'acides aminés d'un produit tronqué de la protéine A N-terminale fixant la choline. Enfin, l'invention concerne des compositions pharmaceutiques, des vaccins et des méthodes diagnostiques et thérapeutiques d'utilisation de ces compositions et de ces vaccins.

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