A polysaccharide-polypeptide conjugate

Details A polysaccharide-polypeptide conjugate A polysaccharide-polypeptide conjugate

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2404111

The invention relates to a method for producing a polysaccharide-polypeptide conjugate by reacting a polysaccharide with a polypeptide comprising at least one free amino group. A polysaccharide carrier having vicinal hydroxy groups is oxidized onto the polypeptide whereby the ring is opened so as to create vicinal aldehyde groups and is reacted with one or more base-instable antigen polypeptide(s) containing at least one free amino group, the polypeptide(s) being bound directly to the polysaccharide carrier via at least one azomethine bond.

L'invention concerne un procédé de fabrication d'un conjugué de polysaccharide et de polypeptide par transformation d'un polysaccharide avec un polypeptide contenant au moins un groupe amine. Ledit procédé consiste à oxyder un porteur de polysaccharide comportant des groupes hydroxyle vicinaux par ouverture du cycle de manière à créer des groupes aldéhyde vicinaux, et à transformer ledit porteur de polysaccharide avec un ou plusieurs polypeptides antigènes instables en milieu acide, comportant un groupe amine libre, le ou les polypeptides étant directement liés au porteur de polysaccharide au moyen d'au moins une liaison azométhine.

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