A practical, cost-effective synthesis of chloromethylated...

C - Chemistry – Metallurgy – 07 – C

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C07C 17/32 (2006.01) C07C 50/28 (2006.01)

Patent

CA 2581420

The present invention relates to a practical and cost-effective method for the synthesis of 5-chloromethylated 2,3-dialkoxy-6-alkyl-1,4-benzoquinones by direct chloromethylation of the corresponding 2,3-dialkoxy-6-alkyl-1,4- benzoquinones. The invention further relates to a method for the preparation of 5-chloromethylated 2,3-dialkoxy-6-alkyl-1,4-benzoquinones starting from a 3,4,5-trialkoxy-1-alkyl-benzene. The invention also relates to a method for the production of Coenzymes Qn, especially coenzyme Q10.

La présente invention concerne un procédé pratique et rentable de synthèse de 2,3-dialkoxy-6-alkyl-1,4-benzoquinones 5-chlorométhylées par chlorométhylation directe des 2,3-dialkoxy-6-alkyl-1,4-benzoquinones correspondantes. L'invention concerne également la fabrication de 2,3-dialkoxy-6-alkyl-1,4-benzoquinones 5-chlorométhylées à partir d'un 3,4,5-trialkoxy-1-alkyl-benzène. De plus, l'invention concerne un procédé de fabrication de co-enzymes Qn, en particulier du co-enzyme Q10.

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