A process for making morphine-6-glucuronide or substituted...

C - Chemistry – Metallurgy – 07 – H

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C07H 13/00 (2006.01) C07D 489/02 (2006.01) C07H 7/033 (2006.01) C07H 13/04 (2006.01) C07H 17/00 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2114838

Morphine-6-glucuronide or substituted morphine-6-glucuronide of formulae (I) is made by conjugation of a glucuronate ester and/or substituted glucuronate ester with morphine or substituted morphine in the presence of a Lewis acid catalyst and in the absence of silver catalysts and barium hydroxide and other heavy metal derivatives.

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