A process for preparation of bisphosphonic acid compounds

Details A process for preparation of bisphosphonic acid compounds A process for preparation of bisphosphonic acid compounds

C - Chemistry, Metallurgy

07

F

C07F 9/38 (2006.01)

Patent

CA 2536229

The present invention provides a novel process for preparation of bisphosphonic acids or salts thereof, e.g. alendronic acid, by reacting a carboxylic acid, phosphorous acid and a halophosphorous compound in a water miscible neutral solvent.

L'invention concerne un procédé d'élaboration d'acides bisphosphoniques ou de sels correspondants, par exemple acide alendronique, par réaction entre un acide carboxylique, un acide phosphoreux et un composé halophosphoreux dans un solvant neutre miscible avec l'eau.

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