A process for preparation of racemic nebivolol

Details A process for preparation of racemic nebivolol A process for preparation of racemic nebivolol

C - Chemistry, Metallurgy

07

D

C07D 311/58 (2006.01) C07D 407/06 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2635479

A process of making racemic [2S*[R*[R*[R*]]]] and [2R*[S*[S*[S*]]]]- (~).alpha.,.alpha.'- [iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1- benzopyran-2-methanol] of the compound of the formula (I) and its pure [2S*[R*[R*[R*]]]]- and [2R*[S*[S*[S*]]]]- enantiomer compounds and pharmaceutically acceptable salts thereof.

Procédé de fabrication de [2S*[R*[R*[R*]]]] et [2R*[S*[S*[S*]]]]-(±).alpha.,.alpha.`- [iminobis(méthylène)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyrane-2-méthanol] du composé de formule (I) et de ses composés énantiomères purs [2S*[R*[R*[R*]]]]- et [2R*[S*[S*[S*]]]], ainsi que des sels pharmaceutiquement acceptables des composés précités.

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