C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 7/08 (2006.01)
Patent
CA 2224598
The present invention relates to a novel process for the preparation of 1-(3- trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanones from 1-halo-3- trialkylsilanyl-benzenes. 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanones are useful for the treatment of Alzheimer's disease and senile dementia. In addition, the present invention relates to a novel process for purifying 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanones utilizing a novel extraction method.
L'invention concerne un nouveau procédé de préparation d'éthanones de 1(3 -trialkylsilylphényle)- 2, 2, 2 - trifluorométhyle éthanones à partir de 1-halo- 3- trialkylsilanylbenzènes. Ces éthanones sont utiles pour traiter la maladie d'Alzheimer et la démence sénile. De plus, l'invention concerne un nouveau procédé de purification d'éthanones de 1-(3-trialkylsilylphényle)- 2, 2, 2 - trifluorométhyle au moyen d'une nouvelle méthode d'extraction.
Fetner Neal J.
Gandolfi Roberto
Klipa Dennis K.
Hoechst Marion Roussel Inc.
Osler Hoskin & Harcourt Llp
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