A process for preparing...

Details A process for preparing... A process for preparing...

C - Chemistry, Metallurgy

07

D

C07D 213/80 (2006.01) C07D 213/803 (2006.01)

Patent

CA 2708442

Intermediates of nevirapine and processes for making intermediates of nevirapine. One such intermediate is N-(2-halo-4-methyl-3-pyridinyl)-2-(cyclopropylamino)- 3- pyridinecarboxamide, which may be produced by (a) treating 2- (cyclopropylamino)-3- pyridine carboxylic acid with a chlorinating agent, to yield 2- (cyclopropylamino)-3- pyridinecarbonyl chloride; and (b) reacting the 2-(cyclopropylamino)-3- pyridine carbonyl chloride with a 2-halo-4-methyl-3-pyridinamine of the formula (see above formula) wherein X is a fluorine, chlorine, bromine or iodine atom, to produce the N-(2-halo-4-methyl-3-pyridinyl)-2-(cyclopropylamino)-3-pyridinecarboxamide.

Intermédiaires de la névirapine et procédés pour synthétiser des intermédiaires de la névirapine. Un de ces intermédiaires est le N-(2-halo-4-méthyl-3-pyridinyl)-2-(cyclopropylamino)-3- pyridinecarboxamide, qui peut être obtenu : a) en traitant de l'acide 2-(cyclopropylamino)-3-pyridinecarboxylique avec un agent de chloration, ce qui génère du chlorure de 2-(cyclopropylamino)-3-pyridinecarbonyle; b) en faisant réagir le chlorure de 2-(cyclopropylamino)-3-pyridinecarbonyle avec une 2-halo-4-méthyl-3-pyridinamine de formule (voir la formule ci-dessus), où X est un atome de fluor, de chlore, de brome ou d'iode, afin de produire le N-(2-halo-4-méthyl-3-pyridinyl)-2-(cyclopropylamino)-3-pyridinecarboxamide.

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