A process for preparing 5-chloro-4-hydroxypyrimidines,...

Details A process for preparing 5-chloro-4-hydroxypyrimidines,... A process for preparing 5-chloro-4-hydroxypyrimidines,...

C - Chemistry, Metallurgy

07

D

C07D 239/36 (2006.01) C07C 229/30 (2006.01) C07D 239/30 (2006.01) C07D 239/34 (2006.01)

Patent

CA 2166897

A process for preparing 5-chloro-4-hydroxypyrimidines, 2- chloro enamines as intermediates in this process and their use The invention relates to a process for preparing com- pounds of the formula Image in which R1 is optionally substituted alkyl, cycloalkyl, aryl or benzyl, in which a chloroacetic ester is convert- ed with ammonia or an ammonium salt into the correspond- ing chloro enamine and the latter is condensed in the presence of a base with formamide. The invention further- more relates to 2-chloro enamines as intermediates in the process.

L'invention concerne un procédé de fabrication de composés ayant la formule (I), dans laquelle R<1> désigne un alkyle, cycloalkyle, aryle ou benzyle éventuellement substitué, caractérisé en ce qu'on transforme un ester chloro-acétique, au moyen d'ammoniac ou d'un sel d'ammonium, en la chlorène-amine correspondante et en ce qu'on condense cette dernière avec le formamide, en présence d'une base. L'invention concerne en outre des 2-chlorène-amines, en tant que produits intermédiaires de ce procédé.

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