A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/34 (2006.01) A61K 9/16 (2006.01) A61K 38/09 (2006.01) A61K 38/23 (2006.01) A61K 38/24 (2006.01) A61K 38/31 (2006.01)
Patent
CA 2055115
ABSTRACT A pharmaceutical composition is prepared in the form of microparticles or of an implant comprising a biodegradable polymer selected from poly-1,4-butylene succinate, poly-2,3-butylene succinate, poly-1,4-buty- lene fumarate and poly-2,3-butylene succinate, incorpo- rating as the active substance the pamoate, tannate, stearate or palmitate of a natural or of a synthetic peptide comprising 3 to 45 amino acids, such as LH-RH, somatostatin, GH-RH or calcitonin, or one of their synthetic analogues or homologues. The preparation comprises dry blending the ingre- dients in the form of powders, pre-compressing and pre- heating the mixture and then extruding the pre- compressed and pre-heated mixture. The product resulting from the extrusion step can then be comminuted and finally sieved.
Heimgartner Frederic
Orsolini Piero
Debio Recherche Pharmaceutique S.a.
Gowling Lafleur Henderson Llp
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