A process for preparing chiral...

C - Chemistry – Metallurgy – 07 – C

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C07C 215/10 (2006.01) C07C 209/56 (2006.01) C07C 213/02 (2006.01) C07C 215/08 (2006.01) C07C 271/06 (2006.01)

Patent

CA 2328124

The present invention relates to a process for preparing chiral (S)-2,3- disubstituted-1-propylamine derivatives and more particularly, to the process for preparing chiral (S)-2,3-disubstituted-1-propylamine derivatives expressed in formula (1), performed in such a manner that a carbonyl group of chiral (S)- 3,4-disubstituted-1-butanecarbonyl derivatives expressed in formula (2) is converted to an amine group through decarbonylation.

L'invention concerne un procédé qui permet de préparer des dérivés chiraux (S) de 1-propylamine 2,3-disubstituée et notamment un procédé qui permet de préparer des dérivés chiraux (S) de 1-propylamine 2,3-disubstituée, représentés par la formule (1). Le procédé consiste à convertir par décarbonylation un groupe carbonyle des dérivés chiraux (S) du 1-butanecarbonyle 3,4-substitué, représentés par la formule (2), en un groupe amine.

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