A process for preparing sustained release tablets

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/22 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 9/52 (2006.01)

Patent

CA 2518734

The present invention relates to a novel process for preparing sustained release tablets containing medicinal compounds and the products prepared by said process. The present invention is directed to a method of preparing a sustained release pharmaceutical composition having a predetermined drug release profile, but which is deviated therefrom by adding a tableting effective amount of a water insoluble or partially insoluble cellulose, to said pharmaceutical composition comprised of a drug in a therapeutically effective amount, and sustained release carrier present in amounts effective retard the release of the drug from the pharmaceutical composition and said cellulose, the latter being present in an aqueous system, the improvement comprising adding to the composition an effective amount of maltodextrin to retard the increase on the rate of release of the drug from the addition of said cellulose thereto.

L'invention concerne un procédé de préparation de comprimés à libération prolongée renfermant des composés médicinaux et les produits préparés au moyen de ce procédé. L'invention concerne un procédé de préparation d'une composition pharmaceutique à libération prolongée présentant un profil de libération de médicament prédéterminé mais déviant de celui-ci par ajout d'une quantité efficace de fabrication de comprimés d'une cellulose insoluble ou partiellement insoluble dans l'eau dans la composition pharmaceutique renfermant un médicament en une quantité efficace sur le plan thérapeutique et un support de libération présent dans des quantités efficaces pour retarder la libération du médicament de la composition pharmaceutique et la cellulose présente dans un système aqueux, l'amélioration résidant dans l'ajout dans la composition d'une quantité efficace de la maltodextrine, afin de retarder l'augmentation de la vitesse de libération du médicament due à l'ajout de cellulose dans celle-ci.

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