A process for producing an amorphous isomer of lansoprazole

Details A process for producing an amorphous isomer of lansoprazole A process for producing an amorphous isomer of lansoprazole

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2502219

It is intended to provide a process for producing unstable amorphous benzimidazole compounds having a proton pump inhibitor function, and stable solid preparations for medicinal use containing these compounds which are produced by blending such an amorphous benzimidazole compound with a nontoxic base such as a basic inorganic salt, forming an intermediate coating layer on the layer containing the active ingredient and further forming an enteric coating layer or a release-controlling coating layer.

L'invention concerne un procédé qui permet de produire des composés de benzimidazole amorphes et instables présentant une fonction d'inhibition de la pompe à protons. L'invention concerne également des préparations solides stables destinées à un usage médical qui contiennent ces composés. Pour obtenir ces préparations, on mélange ces composés de benzimidazole amorphes avec une base non toxique, telle qu'un sel inorganique basique, on forme une couche de revêtement intermédiaire sur la couche contenant l'ingrédient actif et on forme également une couche de revêtement gastro-résistant ou une couche de revêtement contrôlant la libération.

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