A process for producing particles with a converted amorphous...

Details A process for producing particles with a converted amorphous... A process for producing particles with a converted amorphous...

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61J 3/02 (2006.01) A61K 47/26 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2349633

The invention provides a process for crystallization of amorphous and/or meta- stable crystalline regions of preformed particles by treating the particles with a supercritical or subcritical fluid containing an anti-solvent and a solvent. The invention further provides formulations comprising particles produced according to the present process containing one or more pharmacologically active substances and one or more pharmaceutically acceptable excipients, use of said formulations in the treatment of an allergic and/or inflammatory condition of the nose or lungs and methods for treatment of such conditions.

L'invention concerne un procédé de cristallisation de zones cristallines amorphes et/ou métastables de particules préformées, qui consiste à traiter les particules avec un fluide supercritique ou sous-critique contenant un anti-solvant et un solvant. Elle concerne en outre des formulations comprenant des particules produites selon ledit procédé, renfermant au moins une substance pharmacologiquement active et au moins un excipient pharmaceutiquement acceptable, lesdites formulations pouvant servir dans le traitement d'un état allergique et/ou inflammatoire du nez ou des poumons, ainsi que des procédés de traitement de tels états.

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