A process for purification of k-252a

Details A process for purification of k-252a A process for purification of k-252a

C - Chemistry, Metallurgy

07

D

C07D 498/22 (2006.01) C12P 17/18 (2006.01)

Patent

CA 2228471

The present invention provides a purification process of K-252a, which comprises: treating microorganism cells containing K-252a represented by formula (I) (See formula I) with an alkaline solution to convert K-252a into K-252b represented by formula (II) (See formula II) or alkali salts thereof, which are then released out of the cells, methylating K-252b or alkali salts thereof to convert them into K-252a again, and isolating and collecting the resulting K-252a.

La présente invention concerne un procédé de purification des K-252a consistant en un traitement de cellules microbiennes contenant des K-252a représentés par la formule générale (I), au moyen d'une solution alcaline, de façon à convertir les K-252a en K-252b représentés par la formule (II), ou au moyen de l'un des sels alcalins des K-252b de façon à provoquer la fuite du sel alcalin considéré hors des cellules microbiennes. Le procédé consiste ensuite en une méthylation des K-252b ou du sel alcalin qui a ainsi fuit pour reconvertir les K-252b en K-252a, laquelle méthylation est suivie d'un isolement et d'une récupération des K-252a.

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