A process for resolving racemic mixtures and a...

Details A process for resolving racemic mixtures and a... A process for resolving racemic mixtures and a...

C - Chemistry, Metallurgy

07

D

C07D 207/06 (2006.01) C07B 57/00 (2006.01) C07C 211/27 (2006.01) C07C 211/53 (2006.01) C07C 215/08 (2006.01) C07C 233/83 (2006.01) C07C 237/06 (2006.01) C07D 207/09 (2006.01) C07D 207/16 (2006.01)

Patent

CA 2638014

A process for resolving a compound in racemic form comprising the following steps is described: a) reacting a compound in racemic form with a resolving agent, b) forming a diastereoisomeric complex of the resolving agent and an enantiomer of interest, c} separating the enantiomer of interest from the obtained diastereoisomer, wherein such a process is characterized in that said resolving agent is a compound of Formula (I). A diastereoisomeric complex between the resolving agent of Formula (I) and the enantiomer of interest is also described. The process according to the invention allows acid and basic racemic mixtures to be separated.

L'invention concerne un procédé de résolution de composé sous forme racémique, qui consiste à: (a) effectuer la réaction du composé sous forme racémique avec un agent de résolution, (b) produire un complexe diastéréomère constitué de l'agent de résolution et d'un énantiomère, (c) séparer cet énantiomère du diastéréomère obtenu, ce procédé étant caractérisé par le fait que ledit agent de résolution est un composé représenté par la formule (I). L'invention concerne également un complexe diastéréomère constitué de l'agent de résolution représenté par la formule (I) et de l'énantiomère. Ce procédé permet de séparer des mélanges racémiques acides et basiques.

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