C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 227/12 (2006.01) C07C 61/08 (2006.01) C07C 229/00 (2006.01) C07C 229/28 (2006.01)
Patent
CA 2500400
A process for synthesis of 1-(aminomethyl)cyclohexane acetic acid hydrochloride (Gabapentin hydrochloride) comprising: a) Reaction of a mixture of acetic anhydride/ammonium acetate with 1,1-cyclohexane~diacetic acid to yield 3,3-pentamethylene glutarimide; b) Treatment of 3,3-pentamethylene glutarimide with sodium hydroxide in an aqueous solution up to dissolution, dripping the solution thus obtained into a to sodium hydroxide/sodium hypochlorite mixture, which is also aqueous, followed by acidification with hydrochloric acid to yield gabapentine hydrochloride.
L'invention concerne un procédé de synthèse de chlorhydrate d'acide acétique 1-(aminomethyl)cyclohexane (chlorhydrate de Gabapentine) consistant: a) à faire réagir un mélange d'acétate d'ammonium/anhydre acétique avec de l'acide 1,1-cyclohexane-diacétique afin d'obtenir 3,3-pentaméthylène glutarimide; b) à traiter 3,3-pentamethylene glutarimide avec de l'hydroxyde de sodium dans une solution aqueuse jusqu'à la dissolution, à égoutter la solution ainsi obtenue dans un mélange d'hypochlorite de sodium/hydroxyde de sodium, qui est également aqueux, suivi de l'acidification avec de l'acide hydrochlorique afin d'obtenir de l'hydrochloride de gabapentine.
Belotti Paolo
Ferrari Massimo
Ghezzi Marcello
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Erregierre S.p.a.
LandOfFree
A process for synthesis of 1-(aminomethyl)cyclohexane acetic... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with A process for synthesis of 1-(aminomethyl)cyclohexane acetic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and A process for synthesis of 1-(aminomethyl)cyclohexane acetic... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1403160