A process for the conversion of echinocandin class of...

Details A process for the conversion of echinocandin class of... A process for the conversion of echinocandin class of...

C - Chemistry, Metallurgy

07

K

C07K 7/56 (2006.01)

Patent

CA 2327474

The invention relates to a process for the conversion of echinocandin class of peptides to their C4-homotyrosine monodeoxy analogues, particularly mulundocandin to deoxy-mulundocandin, which consists of a single step selective reduction of C4-htyr (homotyrosine) hydroxyl group of echinocandins to their monodeoxy analogues under neutral conditions without prior protection/deprotection of the equally facile C5-Orn (ornithine) hydroxyl group and purification of the monodeoxy compound from the crude reaction mixture.

L'invention concerne un procédé de conversion de peptides de la classe des échinocandines en leurs analogues monodésoxy C4-homotyrosine, notamment de mulundocandine en désoxy-mulundocandine, le procédé consistant à réduire sélectivement en phase unique un groupe hydroxyle de C4-htyr (homotyrosine) d'échinocandines en leurs analogues monodésoxy dans des conditions neutres sans protection préalable/déprotection du groupe hydroxyle C5-Orn (ornithine) également facile et à purifier, du mélange réactionnel brut, le composé monodésoxy.

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