A process for the isolation of a major harmful oxidant from...

Details A process for the isolation of a major harmful oxidant from... A process for the isolation of a major harmful oxidant from...

G - Physics

01

N

G01N 31/00 (2006.01)

Patent

CA 2451504

The components of cigarette smoke, known until now, do not explain the overwhelming hazardous effects of smoking; this invention describes the isolation, identification and procedures for determination of the structure, properties and assay of a relatively stable major harmful oxidant (cs-oxidant) present in the cigarette smoke, the content of which is about 190.plusmn.10 mg per cigarette; the cs-oxidant alone almost quantitatively accounts for the oxidative damage of proteins produced by the aqueous extract of whole cigarette smoke, it is also responsible for the oxidative damage of DNA; since the cs-oxidant is relatively stable, it further explains the deleterious effects of the side stream smoke and passive smoking; a number of chemical compounds / agents including vitamin C have been found to prevent the cs- oxidant induced protein oxidation in vitro.

Les constituants de la fumée de cigarette connus à ce jour ne permettent pas d'expliquer les effets excessivement nocifs produits par l'habitude de fumer. L'invention concerne l'isolement, l'identification ainsi que des procédés permettant de déterminer la structure, les propriétés et le dosage d'un oxydant nocif majeur relativement stable (oxydant de fumée de cigarette) présent dans la fumée de cigarette, dont la teneur est d'environ 190.plusmn.10 µg par cigarette ; cet oxydant est responsable, pratiquement à lui seul, des dommages oxydatifs induits sur les protéines par l'extrait aqueux de fumée complète de cigarette ; il est également responsable des dommages oxydatifs sur l'ADN; comme cet oxydant est relativement stable, il permet d'expliquer les effets délétères de la fumée secondaire et de la fumée passive ; des composés/agents chimiques incluant la vitamine C permettent de prévenir l'oxydation des protéines induite par cet oxydant <i>in vitro</i>.

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