A process for the manufacture of snac (salcaprozate sodium)

Details A process for the manufacture of snac (salcaprozate sodium) A process for the manufacture of snac (salcaprozate sodium)

C - Chemistry, Metallurgy

07

C

C07C 231/00 (2006.01) C07C 231/12 (2006.01) C07C 235/60 (2006.01)

Patent

CA 2662080

Disclosed are improved methods for the synthesis of N-(8-[2-hydroxybenzoyl]- amino) caprylic acid. Certain compounds have been found useful for preventing the formation of a colored impurity when included in an ester hydrolysis reaction. Conducting ester hydrolysis in anaerobic conditions has also been found to minimize the formation of the color impurity. Also disclosed are improved methods for synthesizing the sodium salt of N-(8-[2-hydroxybenzoyl]-amino) caprylic acid.

L'invention concerne des procédés améliorés de synthèse d'acide N-(8-[2-hydroxybenzoyl]-amino) caprylique. Certains composés se sont révélés utiles pour prévenir la formation d'une impureté colorée lorsqu'inclus dans une réaction d'hydrolyse d'ester. On a également découvert que la réalisation d'une hydrolyse d'ester dans des conditions anaérobies réduit au minimum la formation de l'impureté colorée. L'invention concerne également des procédés améliorés de synthèse du sel de sodium d'un acide N-(8-[2-hydroxybenzoyl]-amino) caprylique.

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