A process for the preparation of...

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C - Chemistry, Metallurgy

07

D

C07D 211/08 (2006.01)

Patent

CA 2591404

A process for the preparation of -aryl--piperid-2-yl-acetamides of formula (I) in which Ar is as defined in the disclosure, by catalytic reduction of .alpha.- aryl-.alpha.-pyridin-2-yl-acetamides (II) with rhodium catalysts. Acetamides of formula (II) can subsequently by hydrolysed to the corresponding arylacetic acids, e. g. ritalinic acid, a direct precursor of methylphenidate.

La présente invention concerne un procédé de préparation d~-aryl--pipérid-2-yl-acétamides de formule (I), dans laquelle Ar est tel que défini dans la description, par réduction catalytique de .alpha.-aryl-.alpha.-pyridin-2-yl-acétamides (II) avec des catalyseurs au rhodium. Des acétamides de la formule (II) peuvent ensuite être hydrolysés pour former les acides arylacétiques correspondants, par exemple, l~acide ritalinique, un précurseur direct du méthylphénidate.

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