A process for the preparation of...

Details A process for the preparation of... A process for the preparation of...

C - Chemistry, Metallurgy

25

B

C25B 3/04 (2006.01) C07C 237/26 (2006.01) A61K 31/65 (2006.01)

Patent

CA 2272598

The present invention refers to a process for the preparation of 4-(des--dimethylamino)-tetracyclines, which compounds have a therapeutical application. The starting tetracyclines are treated with a methylating agent and the resulting trimethylammonium salts are reduced by electrolysis in an aqueous solution at acidic pH, in the presence of an adequate electrolyte. A direct electrical current with a potential of 0.5-1.5 volts is applied between two convenient electrodes until the reaction is complete. The 4-(des--dimethylamino)-tetracyclines are isolated by extraction with an organic solvent.

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