A process for the preparation of 3-amino bile acid derivatives

Details A process for the preparation of 3-amino bile acid derivatives A process for the preparation of 3-amino bile acid derivatives

C - Chemistry, Metallurgy

07

J

C07J 43/00 (2006.01) C07J 41/00 (2006.01) C07J 75/00 (2006.01)

Patent

CA 2383505

A process for the preparation of the compounds of general formula (I) in which R1 is H or OH; R2 is H, .alpha.-OH, or .beta.-OH; and R3 is a straight or branched C1-C4 alkyl group or a benzyl group, comprising the reduction of compounds of formula (III) wherein R1, R2 and R3 have the same meanings as in formula (I), in the presence of sodium borohydride.

La présente invention concerne un procédé de préparation de composés représentés par la formule générale (I), dans laquelle R1 représente H ou OH; R2 représente H, alpha -OH, ou beta -OH; et R3 représente un groupe alkyle linéaire ou ramifié C1-C4 alkyle ou un groupe benzyle, consistant à réduire les composés de la formule (III), dans laquelle R1, R2 et R3 ont la même signification que dans la formule (I), en présence de borohydrure de sodium.

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