A process for the preparation of a liposomal, in water...

A - Human Necessities – 61 – K

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A61K 9/127 (2006.01) A61K 31/405 (2006.01) A61K 31/415 (2006.01) A61K 31/57 (2006.01) A61K 38/13 (2006.01) B01J 13/02 (2006.01) A61K 31/71 (1995.01)

Patent

CA 2173387

The inventive process for the preparation of a liposomal, in water dispersive, orally administerable, solid, dry therapeutic formulation, is characterized in that - in a first step at least one biological ac- tive, lipophilic active component, at least one lipid, which forms vesicles, and at least one component, which stabilizes the vesicle structure and/or serves as solu- bilizer, are dissolved in at least one organic solvent, then - in a second step from the obtained homoge- neous solution the organic solvent(s) is (are) removed, then - in a third step the so obtained homogeneous mixture is hydrated, then - in a fourth step the so obtained suspension is treated mechanically during such a long time, until said active component is contained completely and homo- geneous distributed in the formed liposomal particles, then - in a fifth step the water is removed by means of spray drying or by means of a granulating pro- cess and the so obtained solid, which has the form of a powder or of granules, is obtained.

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