A process for the preparation of adapalene

Details A process for the preparation of adapalene A process for the preparation of adapalene

C - Chemistry, Metallurgy

07

C

C07C 69/94 (2006.01) C07C 51/377 (2006.01) C07C 65/26 (2006.01) C07C 67/343 (2006.01)

Patent

CA 2541370

A process for the preparation of a compound of formula (I), or a salt thereof (see formula I) wherein R is H, C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; comprising the reaction between a compound of formula (II) (see formula II) wherein R1 and R2 are independently hydrogen, C1-C8 alkyl, aryl, aryl-C1-C8 alkyl, or R1 and R2, taken together, form a -(CH2)m-V-(CH2)n- group, in which V is NR3 or C(R3)2 wherein R3 is hydrogen, C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; and m and n, which can be the same or different, are 1 or 2; with a compound of formula (III) (see formula III) in which R4 and R5 are independently C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; in the presence of a Ni (II) salt, an organic ligand and a basic agent, to obtain a compound of formula (I) wherein R is C1-C8 alkyl, aryl or aryl-C1-C8 alkyl and, if desired, its conversion to a compound of formula (I) wherein R is hydrogen or to a salt thereof.

Affiliated with

Also associated with

Rating

A process for the preparation of adapalene does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with A process for the preparation of adapalene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and A process for the preparation of adapalene will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2025190