A process for the preparation of alkyl- and...

Details A process for the preparation of alkyl- and... A process for the preparation of alkyl- and...

C - Chemistry, Metallurgy

07

F

C07F 9/38 (2006.01)

Patent

CA 2551230

The invention relates to a process for the preparation of diphosphonic acids by reaction of a carboxylic acid with a mixture of phosphorous acid and phosphorus oxychloride in defined molar ratios and in the absence of solvents. The invention futher relates to ibandronic acid monosodium salt in the amorphous form.

L'invention concerne un procédé de préparation d'acides diphosphoniques par réaction d'un acide carboxylique avec un mélange d'acide phosphoreux et d'oxychlorure phosphoreux dans des rapports molaires définis et en l'absence de solvants. L'invention concerne également un sel de monosodium de l'acide ibandronique sous la forme amorphe.

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