C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 45/61 (2006.01) C07C 221/00 (2006.01) C07C 269/06 (2006.01) C07D 301/00 (2006.01) C07D 301/24 (2006.01) C07D 303/36 (2006.01) C07C 271/18 (2006.01)
Patent
CA 2419751
The present invention relates to a process for the preparation of .alpha.' chloroketones, such as 4-phenyl-3-t-butyloxy-carbonylamino)-2-keto-1- chlorobutane by reacting certain aryl amino acid esters, e.g. N-(2-t- butoxycarbonyl)-L-phenylalanine-4-nitrophenyl ester, with a sulfur ylide compound to form the corresponding keto ylide compound which is then treated with a source of chloride and an organic acid.
La présente invention concerne un procédé de préparation de .alpha.' chlorocétones, par exemple 4-phényl-3-t-butyloxy-carbonylamino)-2-céto-1-chlorobutane, par réaction de certains esters d'acides aminés d'aryle, par exemple un ester N-(2-t-butoxycarbonyl)-L-phénylalanine-4-nitrophényle, avec un composé d'ylide de soufre de façon à obtenir un composé céto ylide correspondant qui est alors traité avec une source de chlorure et un acide organique.
Kronenthal David
Schwinden Mark D.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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