A process for the preparation of an mr contrast agent

Details A process for the preparation of an mr contrast agent A process for the preparation of an mr contrast agent

A - Human Necessities

61

K

A61K 49/06 (2006.01) A61K 49/10 (2006.01) A61K 49/12 (2006.01) A61M 5/36 (2006.01) B01J 10/00 (2006.01) G01R 33/30 (2006.01)

Patent

CA 2372572

The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of said substrate compound; ii) introducing said solution in droplet form into a chamber containing hydrogen gas (H2) enriched in para-hydrogen (p-1H2) and/or ortho-deuterium (o-2H2) whereby to hydrogenate said substrate to form a hydrogenated imaging agent; iii) optionally subjecting said hydrogenated imaging agent to a magnetic field having a field strength below earth's ambient field strength; iv) optionally dissolving said imaging agent in an aqueous medium; v) optionally separating said catalyst from the solution of said imaging agent in said aqueous medium; vi) optionally separating said solvent from the solution of said imaging agent in said aqueous medium; and vii) optionally freezing the solution of said imaging agent in said aqueous medium.

Cette invention a trait à un procédé de préparation d'un agent de contraste pour résonance magnétique, lequel procédé consiste, i) à former dans un solvant une solution d'un composé de substrat non saturé pouvant être hydrogéné ainsi qu'un catalyseur permettant l'hydrogénation de ce substrat, ii), à introduire cette solution sous forme de gouttelettes dans une enceinte renfermant de l'hydrogène en phase gazeuse (H2) enrichi par du para-hydrogène (p-<1>H2) et/ou de l'ortho-deutérium (o-<2>H2) pour hydrogéner le substrat afin de former un agent imageur hydrogéné, iii), éventuellement, à soumettre cet agent imageur hydrogéné aux effets d'un champ magnétique d'une intensité de champ inférieure à l'intensité de champ ambiant terrestre, iv), éventuellement, à faire se dissoudre cet agent imageur dans un milieu aqueux, v), éventuellement, à extraire le catalyseur de la solution d'agent imageur dans le milieu aqueux, vi), éventuellement, à extraire le solvant de la solution d'agent imageur dans le milieu aqueux et, vii), éventuellement, à congeler la solution d'agent imageur dans le milieu aqueux.

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