A process for the preparation of aza-containing bicyclic...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) C07C 215/46 (2006.01)

Patent

CA 2500558

A process for the preparation of a compound of the formula (SEE FORMULA I) having an enantiomeric excess of greater than 0% wherein R1 is selected from the group consisting of hydrogen, alkyl or aryl and R2 and R3 are independently selected from the group consisting of hydrogen, alkyl, aryl, aralkyl or various amino protective groups, comprising cyclizing a compound of the formula, (SEE FORMULA II) wherein R1, R2 and R3 have the above meaning, by refluxing in an organic solvent.

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