A process for the preparation of clopidogrel

Details A process for the preparation of clopidogrel A process for the preparation of clopidogrel

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61P 9/00 (2006.01) C07D 221/00 (2006.01) C07D 333/00 (2006.01) C07D 495/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2485070

A process for the preparation of clopidogrel (1) by reaction of the N, N'-bis- 4,5,6,7-tetrahydro-[3,2-c]-thienopyridyl methane (12) with (r)-2- chlorophenylacetic acid derivatives for formula (13) in which X and R have the meanings as indicated in the disclosure.

La présente invention a trait à un procédé de préparation de clopidogrel (1) par la réaction de N, N'-bis-4,5,6,7-tétrahydro-[3,2-c]-thiénopyridyl méthane (12) avec des dérivées de l'acide chlorophénylacétique (R)-2- de formule (13) dans laquelle X et R sont tels que définis dans la description.

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