A process for the preparation of cyclosporin a from...

Details A process for the preparation of cyclosporin a from... A process for the preparation of cyclosporin a from...

C - Chemistry, Metallurgy

12

P

C12P 21/04 (2006.01) C07K 7/64 (2006.01)

Patent

CA 2142240

The invention relates to a process for the preparation of cyclosporin A from Tolypocladium sp comprising the step of preparing a fermented medium of said Tolypocladium sp. The fungal biomass is extracted of said fermented medium to obtain a methanol extracts which methanol is removed by evaporation to obtain a first residue. An ethyl acetate extract is prepared from the aqueous solution of said first residue which is decolourized and concentrated to obtain a second residue, the second residue is subjected to a step of purification.

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