A process for the preparation of entacapone

Details A process for the preparation of entacapone A process for the preparation of entacapone

C - Chemistry, Metallurgy

07

C

C07C 253/30 (2006.01) C07C 255/37 (2006.01)

Patent

CA 2615318

A process for the preparation of entacapone, in particular as the polymorphic form A, comprising the preparation of a compound of formula (V), as herein defined, by condensation of N,N-diethyl-cyano-acetamide with a compound of formula (IV), as herein defined, in the presence of a strong basic agent; the dealkylation of said compound of formula (V) to obtain entacapone and the crystallization thereof to the polymorphic form A.

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